The Liver-Brain axis

The Liver-Brain axis
The Liver-Brain axis


The liver-brain axis refers to the bidirectional communication between the liver and the brain. Disruptions in this axis can contribute to a variety of diseases. Understanding the interplay between these two organs can help in understanding, diagnosing, and treating a range of medical conditions.

Here are a few key points about the liver-brain axis:

Hepatic Encephalopathy (HE): One of the most well-known manifestations of the liver-brain axis disruption is hepatic encephalopathy, which occurs when the liver fails to detoxify ammonia and other substances. This leads to a buildup of these toxins in the bloodstream, which can cross the blood-brain barrier and affect brain function. Symptoms range from confusion and personality changes to coma in severe cases.

Inflammatory Signaling: The liver, when exposed to harmful substances or during diseases like fatty liver or hepatitis, can produce inflammatory cytokines. These cytokines can reach the brain and might play a role in mood disorders, cognitive changes, and fatigue.

Metabolite Exchange: The liver plays a crucial role in metabolizing various substances in our body, and an imbalance in these can influence brain function. For instance, a buildup of bilirubin in conditions like jaundice can lead to kernicterus, a type of brain damage.

Gut-Brain-Liver Axis: The gut, liver, and brain are interconnected. For instance, the gut microbiota can produce substances that are metabolized by the liver and can then influence brain function. This is often studied in the broader context of the gut-brain axis, but the liver's intermediary role is essential.

Brain Impact on Liver: Just as the liver can influence brain function, the brain can also affect liver function. The central nervous system can influence hepatic glucose production, lipid metabolism, and other liver functions. Chronic stress, for instance, can impact liver function and health through this bidirectional axis.

Alcohol and the Liver-Brain Axis: Chronic alcohol consumption can have deleterious effects on both the liver and the brain. Alcohol can lead to liver diseases like fatty liver, hepatitis, and cirrhosis. Meanwhile, it can also directly damage the brain and contribute to cognitive impairments, mood disturbances, and dependence. Alcohol-induced liver damage can exacerbate brain dysfunction.

Research into the liver-brain axis is ongoing, and a more detailed understanding will likely provide novel therapeutic targets for conditions affecting either or both organs.

 

Neuroscience 2023 and Artificial Intelligence

Neuroscience 2023 Artificial Intelligence

Neuroscience Meeting 2023 SBNeC - Summary of selected neuroscientific topics
(generated by ChatGPT):

Homeostasis Perception and Emotion in Panic

Antropologia Amerindia América Latina

Newborn Behavioral Observation

"Muscle matters: from human disease to human performance"

Transgenerational memories of trauma - epigenetic, physiological and mental health factors

Efeito de Realidade Virtual e Gamificação no Aprendizado

Vida moderna, Ritmos Biológicos, Sono, Homeostasia Fisiológica e Processos Cognitivos

Long-term cognitive and emotional impairments associated to hypercholesterolemia

Short- and long-term effects of ethanol on astrocyte functioning

Caffeine effects on brain development

Obesidade do neurodesenvolvimento ao envelhecimento

Repercussões fisiológicas e celulares da exposição aos pesticidas em períodos críticos do desenvolvimento

Distúrbios do Crescimento Celular

Maternal, Infant and Early Childhood Nutrition

Endocrine Disruptors

Cancer as a developmental disease

Scientific Question and Experimental Design

Scientific Research Integrity

Neuroscience of Obesity

Epilepsy Neuroscience and Perception

The Liver-Brain axis

A fisiologia do feminino

Active Learning to Improve Engagement

The molecular basis of Exercise-induced skeletal muscle mitochondrial biogenesis

Neurochemical Underpinnings of Psychedelic-Induced Ego Dissolution

Recent advances in the neuroendocrine control of hydromineral homeostasis

Psychoneuroimmunology Immunoneuroendocrine interactions

Aproveitando a natureza dinâmica da memória para eliminar experiências traumáticas

Acerca da modificação de memórias episódicas

The biological response of ayahuasca

LSD and creativity

Variabilidade da frequência cardíaca como marcador da integração neurovisceral

Inteligência artificial, psicodélicos, e saúde mental

Efeitos do isolamento social e do enriquecimento ambiental na plasticidade do sistema nervoso

Neurociências e Educação: Reflexões sobre o Transtorno de Déficit de Atenção e Hiperatividade (TDAH)

Cellular and molecular networks underlying psychiatric disorders

NEUROCIÊNCIAS E EDUCAÇÃO: PRÁTICAS BASEADAS EM EVIDÊNCIAS

O que sabemos hoje sobre as expressões faciais na psicopatia?

Aspectos Funcionais e Estruturais da Interação Glia-Neurônio

As bases neurobiológicas da aprendizagem e memória

Buscar formas de otimizar: Efeitos do exercício físico e do exercício cognitivo frente à déficits de memória

O uso de jogos educacionais como estratégia de aprendizagem ativa

Processamento cerebral implícito - a construção de estereótipos

Neuroimagem funcional aplicada ao comportamento humano

O cérebro em tarefas cognitivas e no estado de repouso. Introdução à conectividade funcional

Neurociências e Comportamento Motor

Possível relação entre desenvolvimento motor e o desenvolvimento cognitivo e o desempenho acadêmico do indivíduo

Práticas reprodutíveis em neurociência

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Autor: Jackson Cionek